Indanylacetic acids as PPAR-δ activator insulin sensitizers

A series of indane acetic acid derivatives were prepared which show a spectrum of activity as insulin sensitizers and PPAR-α and PPAR-δ ligands. In vivo data are presented for insulin sensitizers with selectivity for PPAR-δ over PPAR-α.

A novel series of indane acetic acid molecules are insulin sensitizers and have selectivity for PPAR-δ agonist activity over PPAR-α.Figure optionsDownload as PowerPoint slide