کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1366388 | 981590 | 2007 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Synthesis and antibacterial activity of 5-deoxy-5-episubstituted arbekacin derivatives Synthesis and antibacterial activity of 5-deoxy-5-episubstituted arbekacin derivatives](/preview/png/1366388.png)
5-Deoxy-5-episubstituted arbekacin derivatives have been designed and efficiently synthesized. The synthetic compounds showed potent antibacterial activity against both Staphylococcus aureus, including methicillin-resistant S. aureus, and Pseudomonas aeruginosa. In particular, these derivatives were superior to arbekacin against MRSA strains expressing the bifunctional aminoglycoside-modifying enzyme AAC(6′)-APH(2″). The antibacterial activity of the 5-deoxy-5-episubstituted arbekacin derivatives against Pseudomonas aeruginosa was markedly influenced by the efflux system of MexXY/OprM. The 6′-N-methyl derivative of the 5-epi arbekacin was effective against Pseudomonas aeruginosa expressing the aminoglycoside-modifying enzyme AAC(6′).
5-Deoxy-5-episubstituted arbekacin derivatives showed potent antibacterial activity against Staphylococcus aureus, including MRSA and Pseudomonas aeruginosa.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 13, 1 July 2007, Pages 3540–3543