کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1366401 | 981590 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Novel potent antimitotic heterocyclic ketones: Synthesis, antiproliferative activity, and structure–activity relationships
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Novel potent antimitotic heterocyclic ketones: Synthesis, antiproliferative activity, and structure–activity relationships Novel potent antimitotic heterocyclic ketones: Synthesis, antiproliferative activity, and structure–activity relationships](/preview/png/1366401.png)
چکیده انگلیسی
We report the synthesis, antiproliferative activity, and SAR of novel heterocyclic ketones derived from carbazole sulfonamides. Most of the heterocyclic ketones showed strong cytotoxicities. (N-1-Methylindole-5-yl)-(3,4,5-trimethoxyphenyl)-methanone 8b gave the most potent cytotoxicity (9.2–26 nM) against seven human tumor cell lines. The mechanism of action of the heterocyclic ketones appears to involve targeting of tubulin, similar to that of CA-4 and different from the carbazole sulfonamides.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 13, 1 July 2007, Pages 3613–3617
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 13, 1 July 2007, Pages 3613–3617
نویسندگان
Laixing Hu, Jian-dong Jiang, Jinrong Qu, Yan Li, Jie Jin, Zhuo-rong Li, David W. Boykin,