کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1366408 981590 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biaryl cannabinoid mimetics—Synthesis and structure–activity relationship
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Biaryl cannabinoid mimetics—Synthesis and structure–activity relationship
چکیده انگلیسی

Synthesis, in vitro biological evaluation, and structure–activity relationships of a biaryl cannabinoid mimetic 2 are reported. Variations in the substitution pattern yielded a number of agonists with low nanomolar affinity. Replacing the phenol group by a methyl morpholino acetate group led to compound 28, a 500-fold selective CB2 receptor agonist.

A series of novel-substituted biaryl cannabinoid mimetics was synthesized and their biological activity determined.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 13, 1 July 2007, Pages 3652–3656
نویسندگان
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