Antitumor anthraquinones from an endophytic actinomycete Micromonospora lupini sp. nov.

Two novel anthraquinones, lupinacidins A (1) and B (2), have been isolated from the culture broth of a new endophytic actinomycete belonging to the genus Micromonospora. Lupinacidins were found to show significant inhibitory effects on the invasion of murine colon 26-L5 carcinoma cells without inhibiting cell growth.

Two novel anthraquinones, lupinacidins A (1) and B (2), have been isolated from the culture broth of an endophytic actinomycete. Lupinacidins showed significant inhibitory effects on invasion of murine colon 26-L5 carcinoma cells.Figure optionsDownload as PowerPoint slide