کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1366552 981595 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The discovery of highly selective erbB2 (Her2) inhibitors for the treatment of cancer
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
The discovery of highly selective erbB2 (Her2) inhibitors for the treatment of cancer
چکیده انگلیسی

The synthesis and biological evaluation of potent and selective inhibitors of the erbB2 kinase is presented. Based on the 4-anilinoquinazoline chemotype, the syntheses of several new series of erbB2 inhibitors are described with quinazoline and pyrido[4,3-d]pyrimidine cores. The vast majority of these compounds are found to be >100× selective over the closely related EGFR kinase. Two lead compounds are further shown to have low clearance and moderate bioavailability in rat.

The synthesis and biological evaluation of potent and selective inhibitors of the erbB2 kinase is presented. The vast majority of these compounds are found to be >100× selective over the closely related EGFR kinase. Two lead compounds are further shown to have low clearance and moderate bioavailability in rat.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 11, 1 June 2007, Pages 3081–3086
نویسندگان
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