کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1366553 | 981595 | 2007 | 4 صفحه PDF | دانلود رایگان |
The Prins reaction was the basis to synthesize functionalized alkyl chlorodihydropyran derivatives. The inexpensive, stable, and environmentally friendly FeCl3 promotes the cyclization. The method represents an efficient and regioselective manner to obtain in a single step chlorovinyl–TMS oxacycles. The in vitro antiproliferative activities of the compounds were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). Overall, the results show an enhancement in the cytotoxicity exhibited by the new analogs when compared to their parental compounds.
The inexpensive, stable and environmentally friendly FeCl3 promotes the Prins cyclization to synthesize functionalized alkyl chlorodihydropyrans. The method represents an efficient and regioselective manner to obtain in a single step chlorovinyl–TMS oxacycles with enhanced cytotoxicity against human solid tumor cells.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 11, 1 June 2007, Pages 3087–3090