Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity

The synthesis and structure–activity relationships of a series of novel phenoxyphenyl diamine derivatives with affinity for both the histamine H3 receptor and the serotonin transporter is described.

The synthesis and structure–activity relationships of a series of novel phenoxyphenyl diamine derivatives with affinity for both the histamine H3 receptor and the serotonin transporter is described.Figure optionsDownload as PowerPoint slide