کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1366571 981595 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
4-Substituted indazoles as new inhibitors of neuronal nitric oxide synthase
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
4-Substituted indazoles as new inhibitors of neuronal nitric oxide synthase
چکیده انگلیسی

A series of halo-1-H-indazoles has been synthesized and evaluated for its inhibitory activity on neuronal nitric oxide synthase. Introduction of bromine at the C4 position of the indazole ring system provided a compound almost as potent as the reference compound, that is, 7-nitroindazole (7-NI). The importance of position 4 is further demonstrated by the synthesis and pharmacological evaluation of the 4-nitroindazole which was also a potent inhibitor of NOS activity. These compounds also exhibited in vivo NOS inhibitory activity, as attested by potent antinociceptive effects following systemic administration.

The synthesis and in vitro and in vivo pharmacological evaluation of a complete series of substituted indazoles as new inhibitors of nNOS are reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 11, 1 June 2007, Pages 3177–3180
نویسندگان
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