کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1366578 | 981595 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
2-Hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: 2-Hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors 2-Hydroxy-N-arylbenzenesulfonamides as ATP-citrate lyase inhibitors](/preview/png/1366578.png)
چکیده انگلیسی
A novel series of 2-hydroxy-N-arylbenzenesulfonamides were identified to be ATP-citrate lyase (ACL) inhibitors with compound 9 displaying potent in vitro activity (IC50 = 0.13 μM). Chronic oral dosing of compound 9 in high-fat fed mice lowered plasma cholesterol, triglyceride, and glucose, as well as inhibited weight gain.
A novel series of 2-hydroxy-N-arylbenzenesulfonamides were identified to be ATP-citrate lyase (ACL) inhibitors with compound 9 displaying potent in vitro activity (IC50 = 0.13 μM). Chronic oral dosing of compound 9 in high-fat fed mice lowered plasma cholesterol, triglyceride, and glucose, as well as inhibited weight gain.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 11, 1 June 2007, Pages 3208–3211
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 11, 1 June 2007, Pages 3208–3211
نویسندگان
James J. Li, Haixia Wang, Joseph A. Tino, Jeffrey A. Robl, Timothy F. Herpin, R. Michael Lawrence, Scott Biller, Haris Jamil, Randy Ponticiello, Luping Chen, Ching-hsuen Chu, Neil Flynn, Dong Cheng, Rulin Zhao, Bangchi Chen, Dora Schnur,