کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1366688 981600 2007 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
SAR studies on thiazolo[4,5-d]pyrimidine based CXCR2 antagonists involving a novel tandem displacement reaction
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
SAR studies on thiazolo[4,5-d]pyrimidine based CXCR2 antagonists involving a novel tandem displacement reaction
چکیده انگلیسی

As part of a Lead Optimisation programme to identify small molecule antagonists of the human CXCR2 receptor, a series of substituted thiazolo[4,5-d]pyrimidines was prepared via the application of a novel tandem displacement reaction.

The optimisation of antagonists of the CXCR2 receptor is described involving a novel tandem displacement reaction culminating in the synthesis of 6, a novel, potent and metabolically stable lead compound.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 10, 15 May 2007, Pages 2731–2734
نویسندگان
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