Quantitative structure-selectivity relationship for M2 selectivity between M1 and M2 of piperidinyl piperidine derivatives as muscarinic antagonists

A new M2/M1 quantitative structure-selectivity relationship (QSSR) model of piperidinyl piperidine derivatives as muscarinic M2 subtype receptor antagonists was constructed, discussed, and examined. This model could provide solid basis for designing novel molecules with higher antagonistic selectivity to muscarinic receptors.