Discovery of tertiary aminoacids as dual PPARα/γ agonists-I

A novel series of potent dual agonists of PPARα and PPARγ, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure–activity relationships of this series of dual PPARα/γ agonists are described.

A novel series of potent dual agonists of PPARα and PPARγ, the oxybenzylglycines, were identified and explored using a solution-phase library approach. The synthesis and structure–activity relationships of this series of dual PPARα/γ agonists are described.Figure optionsDownload as PowerPoint slide