کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1366847 | 981606 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation of novel antibacterial agents. Replacement of the central aromatic ring with heterocycles
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Preparation of novel antibacterial agents. Replacement of the central aromatic ring with heterocycles Preparation of novel antibacterial agents. Replacement of the central aromatic ring with heterocycles](/preview/png/1366847.png)
چکیده انگلیسی
Discovery of novel antibacterial agents is a significant challenge. We have recently reported on our discovery of novel antibacterial agents in which we have rapidly optimized potency utilizing a parallel chemistry approach. These advanced leads suffer from high affinity for human serum albumin (HSA). In an effort to decrease the affinity for HSA we have prepared a series of heterocyclic analogs, which retained antibacterial activity and demonstrated reduced affinity for HSA.
This paper describes the discovery of anthranilic acid derivatives as potent antibacterial agents against Gram-positive organisms.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 8, 15 April 2007, Pages 2347–2350
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 8, 15 April 2007, Pages 2347–2350
نویسندگان
Jianke Li, Brian D. Wakefield, J. Craig Ruble, Cory M. Stiff, Donna L. Romero, Keith R. Marotti, Michael T. Sweeney, Gary E. Zurenko, Douglas C. Rohrer, Atli Thorarensen,