کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1366950 | 981611 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
α-Methyltryptamine sulfonamide derivatives as novel glucocorticoid receptor ligands
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: α-Methyltryptamine sulfonamide derivatives as novel glucocorticoid receptor ligands α-Methyltryptamine sulfonamide derivatives as novel glucocorticoid receptor ligands](/preview/png/1366950.png)
چکیده انگلیسی
α-Methyltryptamine sulfonamides were identified as human glucocorticoid receptor (hGR) ligands in an ultra high throughput screening (UHTS) campaign. Described will be the hit-to-lead activities, including parallel and single point analog synthesis to map the scaffold. Ligands were identified that exhibited 30 nM binding to hGR. The SAR and selectivity of these compounds will be discussed.
α-Methyltryptamine sulfonamides were identified as human glucocorticoid receptor (hGR) ligands. The SAR and selectivity will be discussed.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 2, 15 January 2007, Pages 315–319
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 2, 15 January 2007, Pages 315–319
نویسندگان
Daniel R. Marshall, Gus Rodriguez, David S. Thomson, Richard Nelson, Allison Capolina,