New competitive inhibitors of cytosolic (NADH-dependent) rabbit muscle glycerophosphate dehydrogenase

We report the synthesis and biochemical evaluation of new competitive inhibitors of the cytosolic (NADH-dependent) glycerophosphate dehydrogenase. The best tested compound, phosphono-propionohydroxamic acid, with a Ki of 6 μM, might be of interest as an anti-obesity drug.

We report the synthesis and biochemical evaluation of new competitive inhibitors of the cytosolic (NADH-dependent) glycerophosphate dehydrogenase. One compound, phosphono-propionohydroxamic acid, with a Ki of 6 μM, might be of interest as an anti-obesity drug.Figure optionsDownload as PowerPoint slide