کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1366988 | 981611 | 2007 | 6 صفحه PDF | دانلود رایگان |
Aryl sulfonamide-based endothelin antagonists were synthesized and covalently linked to the reactive lysine of the m38C2 antibody to create a series of CovX-Bodies. These chemically programmed antibodies behaved as potent endothelin receptor antagonists in vitro and had antitumor efficacy in a prostate cancer xenograft model which, on a molar basis, far exceeded the activity of the parent small molecule.
β-Diketone containing aryl sulfonamide endothelin antagonists were synthesized and covalently linked to the reactive lysine of the antibody m38C2 to create a series of chemically programmed antibodies. These antibodies, named as CovX-Bodies, behaved as potent endothelin receptor antagonists in vitro and showed anti-tumor effect in vivo.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 2, 15 January 2007, Pages 501–506