Design of potent inhibitors of human β-secretase. Part 1

We describe a novel series of potent inhibitors of human β-secretase. These compounds possess the hydroxyethyl amine transition state isostere. A 2.5 Å crystal structure of inhibitor 32 bound to BACE is provided.

We describe a novel series of potent inhibitors of human β-secretase. These compounds possess the hydroxyethyl amine transition state isostere. A 2.5 Å crystal structure of inhibitor 32 bound to BACE is provided.Figure optionsDownload as PowerPoint slide