Synthesis of bisdesmosidic kryptogenyl saponins using the ‘random glycosylation’ strategy and evaluation of their antitumor activity

A bisdesmosidic steroidal saponins library, composed of 16 novel kryptogenin glycosides, was set up via six random glycosylation procedures, wherein two compounds showed their antitumor activity against HeLa cell in the preliminary pharmacological research.

A library of 16 novel bisdesmosidic kryptogenyl saponins was built for investigation of antitumor activity, wherein two compounds showed inhibition against HeLa cells (IC50 = 4.25 μM for 7a and 8.36 μM for 7i).Figure optionsDownload as PowerPoint slide