کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1367105 | 981615 | 2007 | 6 صفحه PDF | دانلود رایگان |
High-throughput screening of the UCB sample collection identified the piperidinyl-sulfonyl benzoic ester 1 as a novel agonist for CB1 receptor with nanomolar affinity. We report here the pharmacological profile of compound 1 as well as preliminary biological activities in pain model. Diverse close analogs of 1 were purchased and the structure–affinity relationships among this novel class are discussed.
High-throughput screening identified the piperidinyl-sulfonyl benzoic ester 1 as a novel agonist for CB1 receptor with nanomolar affinity. We report here the pharmacological profile of compound 1 as well as preliminary biological activities in pain model. Analogs were purchased and the structure–affinity relationships among this novel class are discussed.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 17, Issue 1, 1 January 2007, Pages 272–277