کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1367185 | 981621 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inhibitors of unactivated p38 MAP kinase
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Inhibitors of unactivated p38 MAP kinase Inhibitors of unactivated p38 MAP kinase](/preview/png/1367185.png)
چکیده انگلیسی
Inhibition of the p38 map kinase pathway has been shown to be beneficial in the treatment of inflammatory diseases. The first class of potent p38 kinase inhibitors was the pyridinylimidazole compounds from SKB. Since then several pyridinylimidazole-based compounds have been shown to inhibit activated p38 kinase in vitro and in vivo. We have developed a novel series of pyridinylimidazole-based compounds, which potently inhibit the p38 pathway by binding to unactivated p38 kinase and only weakly inhibiting activated p38 kinase activity in vitro.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 23, 1 December 2006, Pages 6102–6106
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 23, 1 December 2006, Pages 6102–6106
نویسندگان
James Bullington, Dennis Argentieri, Kristin Averill, Demetrius Carter, Druie Cavender, Bohumila Fahmy, Xiaodong Fan, Daniel Hall, Geoffrey Heintzelman, Paul Jackson, Wai-Ping Leung, Xun Li, Ping Ling, Gilbert Olini, Thomas Razler, Michael Reuman,