کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1367192 | 981621 | 2006 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans Synthesis and antiproliferative activity of (2R,3R)-disubstituted tetrahydropyrans](/preview/png/1367192.png)
چکیده انگلیسی
In this study, we synthesized a series of enantiomerically pure (2R,3R)-disubstituted tetrahydropyrans with diverse functional groups. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780 (ovarian cancer), SW1573 (non-small cell lung cancer), and WiDr (colon cancer). Overall, the results show the relevance for antiproliferative activity of the α,β-unsaturated ester side chain at position 2 of the THP ring.
The synthesis and in vitro antitumor activity of a series of enantiomerically pure (2R,3R)-disubstituted tetrahydropyrans against human solid tumor cells are reported.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 23, 1 December 2006, Pages 6135–6138
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 23, 1 December 2006, Pages 6135–6138
نویسندگان
Romen Carrillo, Leticia G. León, Tomás Martín, Víctor S. Martín, José M. Padrón,