New rifabutin analogs: Synthesis and biological activity against Mycobacterium tuberculosis

The synthesis, structure, and biological evaluation of a series of novel rifamycin derivatives, Rifastures (RFA) with potent anti-tuberculosis activity are presented. Some of these derivatives showed higher in vitro activity than rifabutin and rifampicin against not only Mycobacterium tuberculosis strains but also against MAC and Mycobacterium kansasii.

The synthesis and biological evaluation of novel rifamycin derivatives are described.Figure optionsDownload as PowerPoint slide