کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1367309 981625 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Solid-phase combinatorial approach for the optimization of soluble epoxide hydrolase inhibitors
چکیده انگلیسی

A 192-member library of N,N′-disubstituted urea inhibitors was synthesized by a solid-phase method. The ureas were tested for their inhibitory activities against recombinant human soluble epoxide hydrolase. Simple carbocyclic or para/meta-substituted phenyl groups showed inhibition potencies that were equal to or greater than adamantane-based sEH inhibitors, while the presence of bulky or ionizable groups close to the urea group dramatically decreased their activities.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 22, 15 November 2006, Pages 5773–5777
نویسندگان
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