Novel benzimidazole-based MCH R1 antagonists

The identification of an MCH R1 antagonist screening hit led to the optimization of a class of benzimidazole-based MCH R1 antagonists. Structure–activity relationships and efforts to optimize pharmacokinetic properties are detailed along with the demonstration of the effectiveness of an MCH R1 antagonist in an animal model of obesity.

Structure–activity relationships and efforts to optimize pharmacokinetic properties of a class of benzimidazole-based MCH R1 antagonists are described.Figure optionsDownload as PowerPoint slide