Site-Selective DNA cleavage by a novel complex of copper-conjugate of Phen and polyamide containing N-methylimidazole rings

A novel conjugate of 3-Clip-Phen and polyamide containing three N-methylimidazole (Im) rings was synthesized for the targeting human telomeric repeat of 5′-TTAGGG-3′, and the DNA cleaving activity and the sequence selectivity of the complex of copper-conjugate were confirmed by electrospray ionization mass spectrometry.

A novel conjugate of 3-Clip-Phen and polyamide was synthesized for the targeting human telomeric repeat of 5′-TTAGGG-3′, and the DNA cleaving activity and the sequence selectivity of this complex were confirmed by ESI-mass spectrometry.Figure optionsDownload as PowerPoint slide