New benzimidazoles as thrombopoietin receptor agonists

A novel benzimidazole series of small-molecule thrombopoietin receptor agonists has been discovered. Herein, we discuss the preliminary exploration of structure–activity relationships within this chemotype.

The synthesis and SAR of a novel, rationally designed series of benzimidazole TPO receptor agonists are reported.Figure optionsDownload as PowerPoint slide