کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1367496 981635 2006 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and in vitro evaluation of novel derivatives of diphenylsulfide as serotonin transporter ligands
چکیده انگلیسی

As the serotonin transporter (SERT) is involved in several neurodegenerative and psychiatric disorders, radiopharmaceuticals to image the SERT by PET or SPECT would be very valuable in studying these diseases. For the development of imaging agents, we have synthesized novel derivatives of recently reported diphenylsulfide SERT ligands, in which the sulfur atom linking the two phenyl rings was replaced by an oxygen, sulfinyl, sulfonyl, amino or carbon group. Three of these exhibited good to high in vitro affinity (0.5 nM < Ki < 11 nM) and selectivity for the SERT over the other monoamine transporters.

A series of diphenylsulfide derivatives was prepared and their binding affinities for monoamine transporters (SERT, DAT, and NET) are reported.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 5, 1 March 2006, Pages 1297–1300
نویسندگان
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