کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1367528 | 981635 | 2006 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Designing rapid onset selective serotonin re-uptake inhibitors. Part 1: Structure–activity relationships of substituted (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthaleneamine
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Designing rapid onset selective serotonin re-uptake inhibitors. Part 1: Structure–activity relationships of substituted (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthaleneamine Designing rapid onset selective serotonin re-uptake inhibitors. Part 1: Structure–activity relationships of substituted (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydro-1-naphthaleneamine](/preview/png/1367528.png)
چکیده انگلیسی
A series of sertraline analogues 4–39 which possess polar groups on the fused tetrahydronaphthalene ring, targeting reduced Vd as a strategy to reduce Tmax and increase rate of elevation of central 5-HT levels, were prepared. These studies led to the successful identification of 22a, which demonstrated equivalent pharmacology and metabolic stability to 1, but which possessed greatly reduced Vd leading to significantly shorter Tmax, in rat pharmacokinetic studies.
A series of sertraline analogues (4–39) which possess polar groups on the fused tetrahydronaphthalene ring, targeting reduced Vd as a strategy to reduce Tmax and increase rate of elevation of central 5-HT levels, were prepared.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 5, 1 March 2006, Pages 1434–1439
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 5, 1 March 2006, Pages 1434–1439
نویسندگان
Donald S. Middleton, Mark Andrews, Paul Glossop, Geoffrey Gymer, Alan Jessiman, Patrick S. Johnson, Malcolm MacKenny, Michael J. Pitcher, Tony Rooker, Alan Stobie, Kim Tang, Paul Morgan,