کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1367623 | 981641 | 2006 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Isolation and inhibitory activity against ERK Phosphorylation of hydroxyanthraquinones from rhubarb Isolation and inhibitory activity against ERK Phosphorylation of hydroxyanthraquinones from rhubarb](/preview/png/1367623.png)
Five hydroxyanthraquinone compounds were purified from Chinese medicinal herb rhubarb by microwave-assisted extraction and silica gel column isolation. Their structures were identified by spectroscopic analysis. One of them, emodin, was found to block the ERK phosphorylation of PC3 cells at 20 μM. And two other compounds had potent proliferation inhibitory activity on A431 and PC3 cells at 20 μM. Furthermore, crude extracts revealed an antifungal activity stronger than that of purified compounds against several plant pathogens tested. Together, our study suggests that these compounds are biologically active and may lead to development of anticancer medicine.
The extraction and isolation of five hydroxyanthraquinones, chrysophanol, physcion, emodin, aloe-emodin, and rhein from Chinese medicinal herb rhubarb, is developed. And their inhibitory activity against ERK phosphorylation and antifungal activity are performed.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 16, Issue 3, 1 February 2006, Pages 563–568