Design, synthesis, and anti-Helicobacter pylori activity of erythromycin A (E)-9-oxime ether derivatives

The synthesis and anti-Helicobacter pylori (H. pylori) activity evaluation of a new series of erythromycin A (E)-9-oxime ether derivatives are described. These compounds exhibited comparable in vitro anti-H. pylori activity and improved acid stability compared to the reference compound clarithromycin.

Oxime ether formation at C-9 carbonyl and methylation at C-6 hydroxy group of erythromycin A followed by transformation to ketolides gave the derivative II, which exhibited comparable in vitro anti-H. pylori activity and improved acid stability compared to the reference compound clarithromycin.Figure optionsDownload as PowerPoint slide