N-(Aryl)-4-(azolylethyl)thiazole-5-carboxamides: Novel potent inhibitors of VEGF receptors I and II

Novel potent derivatives of 4-(azolylethyl)thiazole-5-carboxamides are described as inhibitors of vascular endothelial growth factor receptor II (VEGFR-2). Many compounds display VEGFR-2 inhibitory activity reaching IC50 < 100 nM in both enzymatic and cell-based phosphorylation assays. The compounds also inhibit the related tyrosine kinase, VEGFR-1, with similar potencies.