Indoloprodigiosins from the C-10 bipyrrolic precursor: New antiproliferative prodigiosin analogs

The condensation of the C-10 methoxybipyrrole precursor (3) of prodigiosin with indoles and a related pyrrole derivative yields novel analogs of prodigiosin. Biological evaluation of these products revealed compounds that inhibit cancer cell proliferation from 50 nM to 50 μM.