کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1367744 | 981645 | 2005 | 5 صفحه PDF | دانلود رایگان |

A series of (S)-N-(1,4-naphthoquinon-2-yl)-α-amino acid methyl esters 3–9, 2-N,N-dialkylamino-1,4-naphthoquinones 10–11 and 2-hydroxy-3-(2′-mercaptoimidazolyl)-1,4-naphthoquinones and their cyclic analogs 12–15 were synthesized and evaluated for antifungal and antibacterial activities. The structure–activity relationships of these compounds were studied and the results show that the compounds 9b and 13c exhibited in vitro antifungal activity against Candida albicans, Cryptococcus neoformans, and Sporothrix schenckii, whereas compound 6a showed in vitro antibacterial activity against Streptococcus faecalis, K. pneumoniae, Escherichia coli, and Staphylococcus aureus.
The synthesis, antifungal, and antibacterial activities of 3–15 are described.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 23, 1 December 2005, Pages 5324–5328