کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1367744 981645 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis and biological evaluation of novel (l)-α-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis and biological evaluation of novel (l)-α-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents
چکیده انگلیسی

A series of (S)-N-(1,4-naphthoquinon-2-yl)-α-amino acid methyl esters 3–9, 2-N,N-dialkylamino-1,4-naphthoquinones 10–11 and 2-hydroxy-3-(2′-mercaptoimidazolyl)-1,4-naphthoquinones and their cyclic analogs 12–15 were synthesized and evaluated for antifungal and antibacterial activities. The structure–activity relationships of these compounds were studied and the results show that the compounds 9b and 13c exhibited in vitro antifungal activity against Candida albicans, Cryptococcus neoformans, and Sporothrix schenckii, whereas compound 6a showed in vitro antibacterial activity against Streptococcus faecalis, K. pneumoniae, Escherichia coli, and Staphylococcus aureus.

The synthesis, antifungal, and antibacterial activities of 3–15 are described.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 23, 1 December 2005, Pages 5324–5328
نویسندگان
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