کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1367828 981650 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synthesis of new carbo- and heterocyclic analogues of 8-HETE and evaluation of their activity towards the PPARs
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Synthesis of new carbo- and heterocyclic analogues of 8-HETE and evaluation of their activity towards the PPARs
چکیده انگلیسی

A new class of dual PPARs α and γ agonists was developed. These compounds are structural analogues of the arachidonic acid metabolite, the 8-(S)-HETE. A versatile strategy has been introduced to prepare the target molecules having different carbo- and heterocyclic cores and to modulate the unsaturations on the side chains. Their affinity towards the PPARs α and γ receptors is reported, together with their transactivation percentage. Most of these derivatives have a good activity as dual agonists but the quinoline-derived products appear as the most promising compounds.

A new class of dual PPARs α and γ agonists has been developed. Most of these derivatives have a good activity but the quinoline-derived products appear as the most promising compounds.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 20, 15 October 2005, Pages 4421–4426
نویسندگان
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