کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1367862 981650 2005 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A new class of high affinity thyromimetics containing a phenyl-naphthylene core
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
A new class of high affinity thyromimetics containing a phenyl-naphthylene core
چکیده انگلیسی

High affinity thyromimetics containing a novel phenyl-naphthylene core are reported. The functionalized core is readily accessible via a Suzuki coupling protocol. Examples of this new class of TR ligands have sub-nanomolar binding affinities for the TRβ receptor and low to modest selectivity for TRβ. They also exhibit an SAR that diverges from other thyromimetics that are based on the diaryl ether core found in 3,5,3′-triiodothyronine.

Examples of this new class of thyromimetics have sub-nanomolar binding affinities for TR, with an SAR that diverges from TR ligands containing a biaryl ether core.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 20, 15 October 2005, Pages 4579–4584
نویسندگان
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