1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors

A series of 1,8-naphthyridine derivatives bearing various substituents in position 3, 4, and 7 of the heterocyclic nucleus have been synthesized and evaluated for their affinity at the bovine and human adenosine receptors. The new compounds were found to lack the affinity toward A1AR, whereas many of them are able to acquire an interesting affinity and selectivity for the A2AAR.

A series of 1,8-naphthyridine derivatives bearing various substituents in positions 3, 4, and 7 of the heterocyclic nucleus have been synthesized and evaluated for their affinity at the bovine and human adenosine receptors. The new compounds were found to lack the affinity towards A1AR, whereas many of them are able to acquire an interesting affinity and selectivity for the A2AAR.Figure optionsDownload as PowerPoint slide