کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1367870 981650 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Minor structural modifications convert a selective PPARα agonist into a potent, highly selective PPARδ agonist
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Minor structural modifications convert a selective PPARα agonist into a potent, highly selective PPARδ agonist
چکیده انگلیسی

We report the solid-phase synthesis and pharmacological evaluation of a new series of small-molecule agonists of the human peroxisome proliferator-activated receptor δ (PPARδ) based on a lead structure from our PPARα program. Compound 33 showed good pharmacokinetics.

We report the solid-phase synthesis and pharmacological evaluation of a new series of small-molecule agonists of the human peroxisome proliferator-activated receptor δ (PPARδ) based on a lead structure from our PPARα program. Compound 33 showed good pharmacokinetics.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 15, Issue 20, 15 October 2005, Pages 4619–4623
نویسندگان
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