Synthesis and antiviral activities of novel N-alkoxy-arylsulfonamide-based HIV protease inhibitors

A series of novel N-alkoxy-arylsulfonamide HIV protease inhibitors with low picomolar enzyme activity and single digit nanomolar antiviral activity is disclosed.

A series of novel N-alkoxy-arylsulfonamide HIV protease inhibitors with low picomolar enzyme activity and single digit nanomolar antiviral activity is disclosed.Figure optionsDownload as PowerPoint slide