کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1368524 981701 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
New sesquiterpene lactones, vernonilides A and B, from the seeds of Vernonia anthelmintica in Uyghur and their antiproliferative activities
ترجمه فارسی عنوان
لاکتون جدید سسکویتپن، ونرونیلید A و B از دانه های Vernonia anthelmintica در اویغور و فعالیت های ضدتکثیری آن
کلمات کلیدی
Vernonia anthelmintica؛ لاکتون سزکوییترپن ؛ فعالیت ضدتکثیری
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

A new guaianolide sesquiterpene lactone, vernonilide A (1), and a new elemanolide sesquiterpene lactone, vernonilide B (2), were isolated from the seeds of Vernonia anthelmintica, together with three known elemanolide sesquiterpene lactones (3–5). The structures of the isolated compounds were elucidated on the basis of physicochemical evidences. Compounds 1, 3, and 4 showed strong antiproliferative activities against three human cancer cell lines (A549, HeLa, and MDA-MB-231), with IC50 values ranging from 0.10 to 1.00 μM. In addition, 5 exhibited significant antiproliferative activities against HeLa and MDA-MB-231 cells, with IC50 values ranging from 1.90 to 2.20 μM. The antiproliferative activities of the acetyl derivatives 6 and 7 prepared from 4 and 3, respectively, against the three cell lines were 4–10-fold weaker than the original activities.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 15, 1 August 2016, Pages 3608–3611
نویسندگان
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