کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1368551 981701 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of bisbenzamidines as inhibitors for matriptase-2
ترجمه فارسی عنوان
ارزیابی بیستبنزامیدین ها به عنوان مهارکننده های ماتریپتاز 2
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

The serine protease matriptase-2 has attracted much attention as a potential target for the treatment of iron overload diseases. In this study, a series of 27 symmetric, achiral bisbenzamidines was evaluated for inhibitory activity against human matriptase-2, against the closely related enzyme human matriptase, as well as against human thrombin, bovine factor Xa and human trypsin. The conformationally restricted piperazine derivative 19 and the oxamide-derived bisbenzamidine 1 were identified as the most potent inhibitors of this series for matriptase-2 and matriptase, respectively.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 15, 1 August 2016, Pages 3741–3745
نویسندگان
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