کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1368604 | 981704 | 2016 | 6 صفحه PDF | دانلود رایگان |
A series of novel 1-(6-amino-3,5-difluoropyridin-2-yl)fluoroquinolone derivatives containing an oxime functional moiety were synthesized and evaluated for their biological activity. Our results reveal that compounds 9a–9c have considerable activity against both of MTB H37Rv ATCC 27294 (MICs: 3.81–7.13 μg/mL) and methicillin-sensitive Staphylococcus aureus strains (MICs: <0.008–0.5 μg/mL).
A series of novel 1-(6-amino-3,5-difluoropyridin-2-yl)fluoroquinolone derivatives containing an oxime functional moiety were synthesized and evaluated for their biological activity. Our results reveal that compounds 9a–9c have considerable activity against MTB H37Rv ATCC 27294 (MICs: 3.81–7.13 μg/mL) and methicillin-sensitive Staphylococcus aureus strains (MICs: <0.008–0.5 μg/mL).Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 9, 1 May 2016, Pages 2262–2267