Preparation and characterization of the pH and thermosensitive magnetic molecular imprinted nanoparticle polymer for the cancer drug delivery

A novel pH and thermosensitive magnetic nanoparticle polymer composite [poly(NIPAAM@Fe3O4 MNPs/TMSPMC/DOX)] was synthesized by radical polymerization of N-isopropylacrylamide (NIPAAM) and the methacrylate functionalized Fe3O4 nanoparticles/DOX complex using AIBN and EGDMA, and used as a drug carrier for the DOX drug delivery. Formation of poly(NIPAAM@Fe3O4 MNPs/TMSPMC/DOX) was confirmed by FTIR, XRD, UV–Vis, VSM, TGA–DTA and SEM. The results showed the high DOX loading controls release. Moreover, it showed the lower critical solution temperature of 40 °C which can be beneficial in cancer drug delivery, since the temperature of cancer cells is higher than normal ones, and DOX can be released selectively in cancer cells.

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