کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1368791 | 981726 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity
ترجمه فارسی عنوان
مشتقات اسید بوتولین فلوئوردار و ارزیابی فعالیت ضد HIV آن ها
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کلمات کلیدی
مشتقات بتولینیک اسید فلوئوردار ؛ بیرویمات؛ فعالیت ضد HIV
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Several fluorinated derivatives of the anti-HIV maturation agent bevirimat (1) were synthesized and evaluated for anti-HIV replication activity. The modified positions were the C-2, C-3, C-28, and C-30 positions, either directly on the betulinic acid (2) skeleton or in the attached side chains. Compound 18, which has a trifluoromethyl group added to C-30 of its isopropenyl group, exhibited similar potency to 1 against HIV-1NL4-3. In total, our current studies support our prior conclusion that C-30 allylic modification is unlikely to be a pharmacophore for anti-HIV activity, but could be a meaningful route to manipulate other properties of 2-related compounds.
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 1, 1 January 2016, Pages 68–71
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 1, 1 January 2016, Pages 68–71
نویسندگان
Jizhen Li, Masuo Goto, Xiaoming Yang, Susan L. Morris-Natschke, Li Huang, Chin-Ho Chen, Kuo-Hsiung Lee,