کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1369293 981772 2014 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Small-molecule quadruplex-targeted drug discovery
ترجمه فارسی عنوان
کشف مواد مخدر کوچک چهار مولکولی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

Repeated guanine tracts in human and other genomes can form higher-order four stranded structures, termed quadruplexes. In the human genome they have particular prevalence in telomeric and promoter regions and also in 5′-UTRs and introns. These structures, if unresolved and stabilised by small molecules, can form impediments to transcription and translation, and thus can be considered as a form of gene targeting. This Digest surveys the major types of quadruplex-binding small molecules that have been designed and studied to date and directs attention to directions where future development of more drug-like compounds is likely to be most productive.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 12, 15 June 2014, Pages 2602–2612
نویسندگان
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