کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1369648 981784 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles
چکیده انگلیسی

A series of structurally-diverse α-ketoamides and α-ketoheterocycles was synthesized and subsequently investigated for inhibitory activity against norovirus 3CL protease in vitro, as well as anti-norovirus activity in a cell-based replicon system. The synthesized compounds were found to inhibit norovirus 3CL protease in vitro and to also exhibit potent anti-norovirus activity in a cell-based replicon system.

Series of structurally-diverse α-ketoamides and α-ketoheterocycles was synthesized and subsequently investigated for inhibitory activity against Norwalk virus 3C protease in vitro, as well as anti-norovirus activity in a cell-based replicon system.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 14, 15 July 2012, Pages 4820–4826
نویسندگان
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