کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1369730 | 981787 | 2016 | 5 صفحه PDF | دانلود رایگان |
A facile DABCO promoted one-pot three component synthesis of a new series of C–C linked bis-heterocycle containing dihydropyrano[c]chromene as highly fused oxa-heteryl group at C-2 position of quinazoline was developed. Quinazoline-2-carbaldehyde, substituted 4-hydroxycoumarin and ethyl cyanoacetate were used as key components in the Knoevenagel–Michael addition reaction to get the titled compounds. These compounds were screened for anti-cancer activity against the breast cancer cell lines of MDA-MB 231, and MDA-MB 453.
The novel carbon–carbon linked dihydropyrano[3,2-c]chromene substituted quinazolines were achieved via DABCO induced Knoevenagel–Michael addition reaction and resulting derivatives were evaluated towards anticancer activity.Figure optionsDownload as PowerPoint slide
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 16, 15 August 2016, Pages 3973–3977