کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1369730 981787 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DABCO-catalyzed one-pot three component synthesis of dihydropyrano[3,2-c]chromene substituted quinazolines and their evaluation towards anticancer activity
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
DABCO-catalyzed one-pot three component synthesis of dihydropyrano[3,2-c]chromene substituted quinazolines and their evaluation towards anticancer activity
چکیده انگلیسی

A facile DABCO promoted one-pot three component synthesis of a new series of C–C linked bis-heterocycle containing dihydropyrano[c]chromene as highly fused oxa-heteryl group at C-2 position of quinazoline was developed. Quinazoline-2-carbaldehyde, substituted 4-hydroxycoumarin and ethyl cyanoacetate were used as key components in the Knoevenagel–Michael addition reaction to get the titled compounds. These compounds were screened for anti-cancer activity against the breast cancer cell lines of MDA-MB 231, and MDA-MB 453.

The novel carbon–carbon linked dihydropyrano[3,2-c]chromene substituted quinazolines were achieved via DABCO induced Knoevenagel–Michael addition reaction and resulting derivatives were evaluated towards anticancer activity.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 16, 15 August 2016, Pages 3973–3977
نویسندگان
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