کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1369873 | 981791 | 2016 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Natural nitric oxide (NO) inhibitors from Chloranthus japonicus
ترجمه فارسی عنوان
مهارکننده های اکسید نیتریک طبیعی (NO) از Chloranthus japonicus
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کلمات کلیدی
Chloranthaceae؛ Chloranthus japonicus ؛ دایمر sesquiterpenoid Lindenane؛ توضیح ساختاری؛ بازدارنده NO
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Eight new lindenane sesquiterpenoid dimers, chlojapolides A–H (1–8), along with 11 known analogues were isolated from the whole plant of Chloranthus japonicus. Their structures including absolute configurations were elucidated by spectral and chemical methods. All the compounds were examined for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW 264.7 macrophages, and compounds 1, 11, 13, and 17 exhibited pronounced inhibition with IC50 values in the range of 6.91–15.75 μM, being more active than the positive control, quercetin (IC50 = 15.90 μM).
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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 13, 1 July 2016, Pages 3163–3166
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 13, 1 July 2016, Pages 3163–3166
نویسندگان
Yan-Qiong Guo, Jing-Jun Zhao, Zhen-Zhen Li, Gui-Hua Tang, Zhi-Min Zhao, Sheng Yin,