کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1369895 981793 2014 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Targeted amplification of delivery to cell surface receptors by dendrimer self-assembly
ترجمه فارسی عنوان
تقویت هدفمند تحویل گیرنده های سطحی سلول به وسیله خود جمع آوری دندریمر
کلمات کلیدی
مجموعه ی سطح سلولی، تقویت هدفمند، دندریمر
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی

Nanometer-scale architectures assembled on cell surface receptors from smaller macromolecular constituents generated a large amplification of fluorescence. A targeted dendrimer was synthesized from a cystamine-core G4 PAMAM dendrimer, and contained an anti-BrE3 monoclonal antibody as the targeting group, several fluorophores and an average of 12 aldehyde moieties as complementary bio-orthogonal reactive sites for the covalent assembly. A cargo dendrimer, derived from a PAMAM G4 dendrimer, contained several fluorophores as the cargo for delivery and five hydrazine moieties as complimentary bio-orthogonal reactive sites. The system is designed to be flexible and allow for facile incorporation of a variety of targeting ligands.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 5, 1 March 2014, Pages 1290–1293
نویسندگان
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