Discovery of thiadiazole amides as potent, S1P3-sparing agonists of sphingosine-1-phosphate 1 (S1P1) receptor

High-throughput screening of GSK compound collection led to the discovery of a novel series of thiadiazole amides as potent and S1P3-sparing sphingosine-1-phosphate 1 (S1P1) receptor agonists. Synthesis, structure and activity relationship, selectivity, and some developability properties are described.

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